The principal toxin ofDelphinium brownii Rydb., and its mode of action |
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| Authors: | V Nambi Aiyar M H Benn T Hanna J Jacyno S H Roth J L Wilkens |
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| Institution: | (1) Department of Biology, The University of Calgary, T2N 1N4 Calgary, Alberta, Canada;(2) Department of Chemistry, The University of Calgary, T2N 1N4 Calgary, Alberta, Canada;(3) Department of Pharmacology and Therapeutics, The University of Calgary, T2N 1N4 Calgary, Alberta, Canada |
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| Abstract: | Summary Examination ofD. brownii, a stock-poison of Western Canada, revealed that the principal toxin was methyllycaconitine: a potent neuromuscular blocking agent which appears to act competitively at nicotinic receptors.We thank the University of Calgary, The National Research Council of Canada, and the Alberta Agriculture Department, for financial assistance. |
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