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Long-term depressor effects of catecholamine neuronal grafts in the third ventricle of the brain in normotensive rats
Authors:R Hashimoto  F Kimura
Institution:(1) Department of Physiology II, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236 Yokohama, (Japan)
Abstract:Summary Neuronal tissue containing A-6 group noradrenalin (NA) neurons of the locus ceruleus, or A-10 group dopamine (DA) neurons of the substantia nigra, was grafted into the third ventricle at the level of the preoptic-anterior hypothalamic region, in normotensive male rats. A significant and long-lasting depressor effect was shown in rats with either graft. In rats with an NA neuron-rich graft, plasma concentrations of arginine-vasopressin (AVP), plasma renin activity (PRA), and corticosterone (CS) decreased significantly, whereas in rats with a DA neuron-rich graft, AVP and PRA concentrations also decreased significantly but CS showed no significant change. Neither NA nor adrenalin in plasma changed significantly in rats with either graft.
Keywords:Blood pressure  catecholamine  brain grafting  central cardiovascular regulation  rat
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