Hypertrophy of pulmonary arteries and arterioles with cor pulmonale in rats induced by seneciphylline,a pyrrolizidine alkaloid |
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| Authors: | K Ohtsubo Y Ito M Saito T Furuya M Hikichi |
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| Institution: | (1) Department of Carcinogenesis and Cancer Susceptibility, Institute of Medical Science, University of Tokyo, Shirokanedai Minato-ku, 108 Tokyo, (Japan);(2) School of Pharmaceutical Science, Kitasato University, Shirokanedai Minato-ku, 108 Tokyo, (Japan) |
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| Abstract: | Summary Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, induced, as do also monoclotaline, etc., a marked arterial and arteriolar hypertrophy of the lung of young Wistar rats a month after a single s. c. injection of 50–80 mg/kg. Cor pulmonale with leftward shift of the ventricular septum was also noted. |
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