| Different Kinetics of Puerarin in Plasma of Normal and Depressed Rats After Oral Administration of Chinese Medicine TZ18 |
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| 引用本文： | 申佳 孟甄 苏慧 邢东明 丁怡 杜力军. Different Kinetics of Puerarin in Plasma of Normal and Depressed Rats After Oral Administration of Chinese Medicine TZ18[J]. 清华大学学报, 2007, 12(4): 394-399. DOI: 10.1016/S1007-0214(07)70059-7 |
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| 作者姓名： | 申佳 孟甄 苏慧 邢东明 丁怡 杜力军 |
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| 作者单位： | Laboratory of Pharmaceutical Sciences Department of Biological Sciences and Biotechnology Tsinghua University，Laboratory of Pharmaceutical Sciences Department of Biological Sciences and Biotechnology Tsinghua University，Laboratory of Pharmaceutical Sciences Department of Biological Sciences and Biotechnology Tsinghua University，Laboratory of Pharmaceutical Sciences Department of Biological Sciences and Biotechnology Tsinghua University，Laboratory of Pharmaceutical Sciences Department of Biological Sciences and Biotechnology Tsinghua University，Laboratory of Pharmaceutical Sciences Department of Biological Sciences and Biotechnology Tsinghua University，Beijing 100084 China Beijing 100084 China Beijing 100084 China Beijing 100084 China Beijing 100084 China Beijing 100084 China |
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| 摘 要： | The objective of this study is to quantify the puerarin in rat plasma following oral administration of TZ18 and compare the pharmacokinetics characteristics of puerarin in normal rats with that in depression model rats. A high performance liquid chromatography method was used to quantify the puerarin due to its good selectivity and linearity (coefficient correlation, r2 = 0.9991) within the tested range (0.028-0.889 μg·mL-1). Intra- and inter-day precision coefficients of variation and accuracy bias were acceptable (Maximum coeffi- cient of variation was 5.74% for intra-day and 3.09% for inter-day) over the entire range. The recoveries were found to be 98.3%, 101.4%, and 103.4% for concentrations of 0.028, 0.222, and 0.444 μg·mL-1, re- spectively. The concentration-time curves for both normal rats and depression model rats were fit to a two- compartment model with the first order absorption. The results show significant differences in the main phar- macokinetic parameters of peak time, peak concentration, and the area under the concentration-time curve between the two kinds of rats.
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| 关 键 词： | 动物模型 药动学 等离子体 中医 |
| 收稿时间： | 2006-10-18 |
| 修稿时间： | 2006-10-18 |
Different Kinetics of Puerarin in Plasma of Normal and Depressed Rats After Oral Administration of Chinese Medicine TZ18 |
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| SHEN Jia,MENG Zhen,SU Hui,XING Dongming,DING Yi,DU Lijun. Different Kinetics of Puerarin in Plasma of Normal and Depressed Rats After Oral Administration of Chinese Medicine TZ18[J]. Tsinghua Science and Technology, 2007, 12(4): 394-399. DOI: 10.1016/S1007-0214(07)70059-7 |
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| Authors: | SHEN Jia MENG Zhen SU Hui XING Dongming DING Yi DU Lijun |
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| Affiliation: | Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China |
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| Abstract: | The objective of this study is to quantify the puerarin in rat plasma following oral administration of TZ18 and compare the pharmacokinetics characteristics of puerarin in normal rats with that in depression model rats. A high performance liquid chromatography method was used to quantify the puerarin due to its Intra- and inter-day precision coefficients of variation and accuracy bias were acceptable (Maximum coefficient of variation was 5.74% for intra-day and 3.09% for inter-day) over the entire range. The recoveries spectively. The concentration-time curves for both normal rats and depression model rats were fit to a twocompartment model with the first order absorption. The results show significant differences in the main pharmacokinetic parameters of peak time, peak concentration, and the area under the concentration-time curve between the two kinds of rats. |
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| Keywords: | puerarin depression rat model pharmacokinetics |
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