| CFD-ACE＋软件对PCR微芯片传热过程的数值模拟和分析 |
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| 引用本文： | 陈飞,;王为术,;李具峰,;邹志青,;金庆辉,;赵建龙. CFD-ACE＋软件对PCR微芯片传热过程的数值模拟和分析[J]. 科技信息, 2008, 0(15): 7-8 |
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| 作者姓名： | 陈飞, 王为术, 李具峰, 邹志青, 金庆辉, 赵建龙 |
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| 作者单位： | 华北水利水电学院 河南郑州450011(陈飞，王为术)，河北省电力研究院 河北石家庄050021(李具峰)，中国科学院上海微系统与信息技术研究所 中国上海200050(邹志青，金庆辉，赵建龙) |
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| 基金项目： | ※基金项目：华北水利水电学院高层次人才启动项目和校青年基金（HSQJ2006003）资助. |
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| 摘 要： | 针对基于MEMS技术的PCR微芯片温度控制难的问题，通过对该芯片的传热过程进行简化并建立物理模型和数学模型，对芯片内部的热传导和温度变化过程进行了理论推导分析。利用CFD-ACE＋软件对芯片的热传导过程进行了数值模拟。模拟结果表明，该芯片具有较高的升、降温速度。芯片在自行构建的温度控制系统下进行了热循环反应，对GUS基因成功实现了扩增。
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| 关 键 词： | PCR微芯片 传热 CFD-ACE+软件 数值模拟 |
Simulation and Analysis of Heat Transfer for PCR Microchip by Using CFD-ACE Software |
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| CHEN Fei,WANG Wei-Shu,LI Ju-Feng,ZOU Zhi-Qing,JIN Qing-Hui,ZHAO Jian-Long. Simulation and Analysis of Heat Transfer for PCR Microchip by Using CFD-ACE Software[J]. Science, 2008, 0(15): 7-8 |
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| Authors: | CHEN Fei WANG Wei-Shu LI Ju-Feng ZOU Zhi-Qing JIN Qing-Hui ZHAO Jian-Long |
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| Affiliation: | CHEN Fei1,WANG Wei-Shu1,LI Ju-Feng2,ZOU Zhi-Qing3,JIN Qing-Hui3,ZHAO Jian-Long3 |
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| Abstract: | A novel PCR (polymerase chain reaction) microchip was designed and fabricated by MEMS technology, which was integrated with micro heaters and temperature sensors in chip for rapid thermal cycling. Heating and cooling rates are evaluated theoretically by setting up a simplified heat transfer model of the microchip. The processes of heat conduction and diffusion are simulated by using CFD-ACE software. Simulation shows that the chip has high temperature rising and cooling rates. By combining peripheral thermal control system, the GUS gene is successfully amplified in chip. |
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| Keywords: | PCR microchip heat transfer CFD-ACE software numerical simulation |
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