靶向振荡磁场发生器的研制

针对药物靶向治疗中难以产生足够磁场强度和梯度的交流脉冲磁场问题,提出了采用双极性脉冲电流产生靶向引导磁场的新思路,研制了一种适用于磁性药物聚焦和控制药物释放的靶向振荡磁场发生器,其主电路拓扑利用负载能量回馈,减少电路损耗,提高电流幅值和电流脉冲陡度,从而提高磁场强度和磁场强度变化率。该装置输出频率0.125~32 Hz,磁感应强度达1.3 T,正弦磁场、单极性和双极性脉冲磁场的磁性微粒聚焦效果和振荡效果的对比实验,证明双极性陡脉冲强磁场更适用于靶向治疗。双极性脉冲强磁场中磁性微粒聚集速度快,聚焦效果好,振荡现象明显。

Development of a targeting oscillating magnetic field generator

Focusing on the key equipment of targeting therapy,a novel method of adopting bipolar pulse current to generate guiding magnetic field was proposed.A high targeting oscillating magnetic field generator also was developed.These innovations were used to control the focus and to release magnetic drugs to in an effort to treat cancer.Based on the proposed transmission circuit,the load inductance energy feedback circuit reduces loss,improves the current amplitude and strengthens the magnetic field.Work frequency of the designed equipment is 0.125 Hz to 32 Hz,and the magnetic induction intensity reaches 1.3 T.Experimental results show that,compared to sinusoidal and unipolar pulse magnetic fields,the bipolar steep pulse magnetic field is more suitable for magnetic drug focus and targeting therapy,and has better performance of controlling the focus and release of magnetic particles.