Molecular mimicry: a critical look at exemplary instances in human diseases |
| |
| Authors: | Rose N R Mackay I R |
| |
| Institution: | (1) Department of Pathology and Department of Molecular Microbiology and Infectious Disease, The Johns Hopkins Medical Institutions/E5014, 615 North Wolfe Street, Baltimore (Maryland 21205, USA), e-mail: nrrose@jhsph.edu, US;(2) Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3168 (Australia), AU |
| |
| Abstract: | Molecular mimicry, the concept that antigenic determinants of microorganisms resemble antigenic determinants of the host,
is frequently cited as a plausible mechanism to account for the association of infection and autoimmune disease. Based on
analogous sequences of amino acids or on cross-reactions of monoclonal antibodies, numerous examples of such mimicry have
been reported. There are, however, no clear examples of a human disease caused by molecular mimicry. |
| |
| Keywords: | , Autoimmunity, molecular mimicry, myocarditis, type 1 diabetes, Lyme disease, rheumatoid arthritis, ankylosing spondylitis,,,,,,multiple sclerosis, |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
