Role of lactone ring of aflatoxin B1 in toxicity and mutagenicity |
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Authors: | L. S. Lee J. J. Dunn A. J. DeLucca A. Ciegler |
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Affiliation: | (1) Southern Regional Research Center, Science and Education Administration, U.S. Department of Agriculture, 70179 New Orleans, LA, USA |
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Abstract: | Summary Cleavage of the lactone ring of aflatoxin B1 results in a nonfluorescent compound that has greatly reduced biological activity. Mutagenicity, as measured by the Ames test, is reduced 450-fold compared to that of B1, and toxicity, as measured by the chick embryo test, is reduced 18-fold. |
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