| "两肾一夹"肾性高血压大鼠模型的改进 |
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| 引用本文： | 戴勇,彭武建,徐卓佳. "两肾一夹"肾性高血压大鼠模型的改进[J]. 实验动物科学, 2006, 23(2): 60-62 |
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| 作者姓名： | 戴勇 彭武建 徐卓佳 |
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| 作者单位： | 1. 暨南大学第二附属医院,深圳,518020
2. 温州医学院第一附属医院,温州,325000 |
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| 摘 要： | 目的建立一种适于普遍应用的大鼠肾性高血压模型的系统方法。为开展高血压的实验研究,建立大鼠肾性高血压实验模型的新方法。方法采用丝线和针灸针缩窄方法代替银夹。结果高血压成功率达86%,术后两周血压明显增高。结论此模型可以在一般的实验室条件下建立并有较高的成功率,符合高血压实验研究的需要。
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| 关 键 词： | 肾血管性高血压 模型制作 大鼠 |
| 文章编号： | 1006-6179(2006)02-0060-03 |
| 修稿时间： | 2005-09-20 |
Modification of Gloidblatt 2K1C Hypertension Model in Rats |
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| DAI Yong,PENG Wu-jian,XU Zhou-jia. Modification of Gloidblatt 2K1C Hypertension Model in Rats[J]. Laboratory Animal Science, 2006, 23(2): 60-62 |
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| Authors: | DAI Yong PENG Wu-jian XU Zhou-jia |
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| Abstract: | Objective To expand laboratory investigation of hypertension and study a new method for establishing renovascilar hypertensive rat model.Methods The acupuncture needle and silkgature were used to instead of clip to narrow the renal artery of rats.Results A success rate of 86% was got in our experiment.The obviously elevated SBP in rats were showed two weeks after operation respectively.Conclusion This modified methods is feasible and with a higher successful rate and can be used to study hypertension further. |
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| Keywords: | Renovascilar hypertensive Animal model Rat |
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