Effect of pyrophosphate and orotidine monophosphate on cytosine deaminase regulatory properties |
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| Authors: | T P West |
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| Institution: | (1) Present address: Department of Biological Sciences, University of Southern Mississippi, 39406 Mississippi, Hattiesburg, USA;(2) Department of Biochemistry and Biophysic, Texas A & M University, 77843 College Station, Texas, USA |
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| Abstract: | Summary The maximal velocity of the reaction (Vmax) and the half-saturation constant (K0.5) values of theS. typhimurium cytosine deaminase were altered in the presence of its effectors, pyrophosphate and orotidine monophosphate. From the kinetics of orotidine monophosphate inhibition of cytosine deaminase, it was characterized as a mixed-type noncompetitive inhibitor. |
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| Keywords: | Cytosine deaminase kinetics pyrophosphate orotidine monophosphate |
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