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Common variants at 11p13 are associated with susceptibility to tuberculosis |
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| Authors: | Thye Thorsten Owusu-Dabo Ellis Vannberg Fredrik O van Crevel Reinout Curtis James Sahiratmadja Edhyana Balabanova Yanina Ehmen Christa Muntau Birgit Ruge Gerd Sievertsen Jürgen Gyapong John Nikolayevskyy Vladyslav Hill Philip C Sirugo Giorgio Drobniewski Francis van de Vosse Esther Newport Melanie Alisjahbana Bachti Nejentsev Sergey Ottenhoff Tom H M Hill Adrian V S Horstmann Rolf D Meyer Christian G |
| Affiliation: | Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. |
| Abstract: | After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11). |
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