| 不同缺血时间对脑缺血/再灌注损伤大鼠神经行为学的影响 |
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| 引用本文： | 尚远宏,田金凤,李松青,徐晓玉.不同缺血时间对脑缺血/再灌注损伤大鼠神经行为学的影响[J].西南民族大学学报(自然科学版),2015,41(5):539-543. |
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| 作者姓名： | 尚远宏 田金凤 李松青 徐晓玉 |
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| 作者单位： | 西南大学 药学院 重庆市药效评价工程技术研究中心 攀枝花学院 生物与化学工程学院 医学院 干热河谷特色生物资源研发四川省高校重点实验室,攀枝花学院 生物与化学工程学院 医学院 干热河谷特色生物资源研发四川省高校重点实验室,攀枝花学院 生物与化学工程学院 医学院 干热河谷特色生物资源研发四川省高校重点实验室,西南大学 药学院 重庆市药效评价工程技术研究中心 |
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| 基金项目： | 重庆市科技攻关项目(CSTC,2010AC5011)，攀枝花市社会发展科技计划项目（2014TX -10-3），四川省教育厅重点基金项目（14ZA0345，15ZA0370），四川省高校重点实验室开放基金项目(GR-2013-E-02，GR-2015-E-01). |
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| 摘 要： | 为探讨不同缺血时间对脑缺血/再灌注损伤大鼠神经行为学的影响,利用线栓法复制脑缺血/再灌注损伤模型,考察缺血1 h、2 h和4 h后再灌注1 d、4 d、7 d和14 d的不同时间点时大鼠神经功能缺损评分,TTC染色测梗死面积.结果显示缺血2 h组存活率较高,为中度神经功能缺损程度.结论为缺血2 h为最适合的造局灶性缺血/再灌注模型的缺血时间,可以为评定后续实验中药物药效指标和选择缺血时间窗提供重要参考.
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| 关 键 词： | 脑缺血/再灌注损伤 缺血时间 神经行为学 |
| 收稿时间： | 2015/7/9 0:00:00 |
| 修稿时间： | 2015/8/22 0:00:00 |
Neurobehavioral results of the different ischemic time after the focal cerebral ischemia-reperfusion in rats |
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| SHANG Yuan-hong,TIAN Jin-feng,LI Song-qing and XU Xiao-yu.Neurobehavioral results of the different ischemic time after the focal cerebral ischemia-reperfusion in rats[J].Journal of Southwest University for Nationalities(Natural Science Edition),2015,41(5):539-543. |
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| Authors: | SHANG Yuan-hong TIAN Jin-feng LI Song-qing and XU Xiao-yu |
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| Institution: | College of Pharmaceutical Sciences,Southwest University,Chongqing Engineering Research Center for Pharmacodynamics Evaluation,CollegeSof biological and chemical Engineering,College of Medicine,Key Laboratory of Dry-hot Valley Characteristic Bio-Resources Development at university of Sichuan Province,Panzhihua University,School of Biological and Chemical Engineering, College of Medicine, Key Laboratory of Dry-hot Valley Characteristic Bio-Resources Development at University of Sichuan Province, Panzhihua University and College of Pharmaceutical Sciences,Southwest University,Chongqing Engineering Research Center for Pharmacodynamics Evaluation |
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| Abstract: | To explore the neurobehavioral results of different ischemic time after the focal cerebral ischemia reperfusion in rats, a cerebral ischemia-reperfusion (I/R) model was established using the line in the left middle cerebral artery occlusion (MCAO) of rats and test neuro-behavioral evaluation by a method of modified neurological severity scores (mNSS) in ischemia for l h, 2 h, 4 h and reperfusion for l d, 4 d, 7 d and 14 d. The area of the cerebral infarction was estimated by 2% TTC staining. Results showed that the survival rate in ischemia for 2 h group was relatively high and the neurological function defect belonged to the moderate degree. 2 h after ischemia is the most appropriate ischemia time in focal ischemia-reperfusion model, and it might be one important reference for assessing pharmacodynamic indexes and the selection of ischemia time window in related research. |
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| Keywords: | cerebral ischemia-reperfusion ischemic time neuro-behavioral evaluation |
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