Type III (Arthus) allergic reactions and endotoxin toxicity in guinea-pigs |
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| Authors: | A J McLean J Dowling |
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| Institution: | (1) Monash University Department of Medicine and Department of Pathology, Prince Henry's Hospital, South Melbourne, Victoria, Australia;(2) Present address: Department of Pharmaceutics, Faculty of Health Sciences, State University of New York at Buffalo, Cooke-Hochstetter Complex, 14260 Amherst, New York, USA |
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| Abstract: | Summary Lipopolysaccharide (endotoxin) fromE. coli cells produced lethal effects in guinea-pigs. Endotoxin caused no visible dermal change in normal animals, but produced skin reactions characterized by specific Arthus-type (Type III immune hypersensitivity) vascular inflammation in immunized animals. It is concluded that Arthus allergic reactions were evoked by endotoxin, however, endotoxin lethal toxicity appears independent of this process.Acknowledgment. Supported by a grant from the National Health and Medical Research Council of Australia. |
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