呋喃取代的多芳基咪唑的合成与表征

以呋喃甲醛为原料,在维生素B1的促进下合成出呋喃偶姻,再以呋喃偶姻为原料,通过吡啶氧化,在硫酸铜溶液中合成出呋喃偶酰。以呋喃偶酰、芳香醛、醋酸铵和杂环胺为原料,分别采用一锅3组分和一锅4组分合成法制备了含1个呋喃基团、2个呋喃基团和3个呋喃基团的多芳基1H-咪唑化合物。其中,采用苯偶酰、醋酸铵和糠醛合成了2-(呋喃基-2)-4,5-二苯基-1H-咪唑衍生物;以呋喃偶酰、醋酸铵和苯甲醛合成了4,5-二呋喃基-2-苯基-1H-咪唑衍生物;以呋喃偶酰、2-甲基呋喃、醋酸铵和糠醛合成了4,5-二(呋喃基2)-1-(2-呋喃甲基)-2-苯基-1H-咪唑衍生物。并采用IR,1H NMR对所合成的呋喃基取代的多芳基1H-咪唑衍生物的结构进行了表征和确认。

Synthesis and characterization of furanyl substituted multi-aryl imidazoles derivatives

In this paper, furanyl benzoin was synthesized with furancarboxaldehyde and vitamin B1,then the furanyl benzoin as a raw material, furanyl benzil was synthesized in a copper sulfate solution by the oxidation of pyridine, furanyl benzil, substituted benzaldehyde, ammonium acetate and various amino compounds as raw materials, to synthesis one furyl group、 two furyl group or three furyl group polyaryl 1H-imidazol-compounds by one pot multicomponents reaction. Benzil, ammonium acetate and furfuralsynthesis the 2-（furan-2-yl）-4,5-substituted phenyl-1H-imidazole derivatives. Furanyl benzil, ammonium acetate and benzaldehyde synthesis the 4,5-（furan-2-yl）-2-substituted phenyl-1H-imidazole derivatives. Furanyl benzil, ammonium acetate、furfural and 2-methylfuran synthesis the 4,5-bis（2 furyl）-1-（2-furylmethyl）-2-phenyl-1H-imidazole derivatives. Their structures were characterized and confirmed by IR and 1 H NMR spectrum.