Sulfamidés et acides nucléiques

Summary The ribonucleic and thymonucleic acids are antisulphamide forEremothecium Ashbyii and for aSaccharomyces. This effect is due partly to purines, first of all to adenine, but not to any pyrimidines. ForSaccharomyces, the action of adenine is 1/10 of that of PAB acid. The suggestion is made that the bacteriostatic effect of the sulphamide is connected with the nucleic acids of the cytoplasma and the nucleus. Those are studied cytologically with help of the ribonuclease-method ofBrachet. Strong differences appear between the normal cells and the intoxicated ones.