6-烷氧基-2-甲硫基嘌呤衍生物的合成

6-烷氧基-2-烷硫基嘌呤是一类潜在的具有生理功能和药理活性的化合物。本文以2-氨基-6-氯嘌呤(1)为原料，与烯丙基溴反应得9-烯丙基-2-氨基-6-氯嘌呤(2)；随后和醇钠反应，合成相应的6-位芳香亲核取代产物(3)；再进一步与亚硝酸异戊酯和二甲二硫醚发生重氮-烷硫化反应，生成9-烯丙基-6-烷氧基-2-甲硫基嘌呤(4)；最后经硼氢化-氧化反应可得9-(3-和2-羟基丙基)-6-烷氧基-2-甲硫基嘌呤化合物(5和6)。经过4步反应，共合成了13种新化合物，其结构经1H-NMR、13C-NMR和HRMS等表征确证。

Synthesis of 6-alkyloxy-2-methylthiopurine derivatives

6-Alkyloxy-2-alkylthiopurine derivatives exhibiting potential pharmaceutical bioactivities have been synthesized using 2-amino-6-chloropurine as the starting material.After allyl substitution,azo-methylthionation,and then aromatic nucleophilic substitution,2-amino-6-chloropurine can afford 6-alkyloxy-9-allyl-2-methylthiopurine.Further hydroboration-oxidation processes gave rise to 6-alkyloxy-9-(3-and 2-hydroxypropyl)-2-methylthiopurine derivatives.Thirteen new compounds were synthesized and all compounds were identified by 1H-NMR and 13C-NMR spectroscopy,and high-resolution mass spectrometry.