| 通过Knoevenagel缩合反应液相合成多取代的丙烯酸甲酯 |
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| 引用本文： | 商永嘉,金杰.通过Knoevenagel缩合反应液相合成多取代的丙烯酸甲酯[J].安徽师范大学学报(自然科学版),2007,30(3):308-312. |
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| 作者姓名： | 商永嘉 金杰 |
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| 作者单位： | 安徽师范大学,化学与材料科学学院,安徽,芜湖,241000;安徽师范大学,化学与材料科学学院,安徽,芜湖,241000 |
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| 基金项目： | Supported by the Nature Science Foundation of Anhui Province (03046303)，the Natural Science Foundation of Education Administration of Anhui Province (2006kj117B) |
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| 摘 要： | 以聚乙二醇作为树脂支持液相合成了多取代的丙烯酸甲酯类化合物.商品化的聚乙二醇4000与2,2 ,6-三甲基-4-氢-1,3-二英-4-酮反应得到聚乙二醇支持含活化亚甲基化合物,然后与芳醛进行Knoevenagel缩合反应合成多取代的丙烯酸甲酯类化合物,收率和纯度都很高.
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| 关 键 词： | 液相有机合成 Knoevenagel反应 聚乙二醇 丙烯酸甲酯 |
| 文章编号： | 1001-2443（2007）03-0308-05 |
| 收稿时间： | 2007-01-10 |
| 修稿时间： | 2007-01-10 |
Liquid-Phase Synthesis of Multisubstituted Acrylic Acid Methyl Ester Via the Knoevenagel Condensation |
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| SHANG Yong-Jia,JIN Jie.Liquid-Phase Synthesis of Multisubstituted Acrylic Acid Methyl Ester Via the Knoevenagel Condensation[J].Journal of Anhui Normal University(Natural Science Edition),2007,30(3):308-312. |
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| Authors: | SHANG Yong-Jia JIN Jie |
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| Institution: | College of Chemistry and Materials Science, Anhui Key Laboratory of Functional Molecular Solids, Anhui Normal University, Wuhu 241000,China |
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| Abstract: | The liquid-phase synthesis of multisubstituted acrylic acid methyl ester using poly (ethylene glycol) as support is reported. The commercially available resin PEG4000 was treated with 2,2,6-trimethyl-4H-1, 3-dioxin-4-one to get a polymer supported active methylene. Then, the Knoevenagel reaction of soluble polymer-supported active methylene with a series of aromatic aldehydes gave anticipated products in high yields and excellent purities. |
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| Keywords: | liquid-phase synthesis Knoevenagel reaction poly (ethylene glycol) (PEG) and acrylic acid methyl ester |
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