Dexamethasone suppression of ovulation in PMS-treated immature rats |
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| Authors: | K. F. A. Soliman C. A. Walker |
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| Affiliation: | (1) School of Pharmacy, Florida A and M University, 32307 Tallahassee, Florida, USA |
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| Abstract: | Summary A single injection of 2.0 mg/kg dexamethasone (DXM) administered at 51 h after pregnant mare serum gonadatropin (PMS) treatment inhibited both ovulation and luteinization. S.c. injection of human chorionic gonadotropin (HGG) caused ovulation ond luteinization in DXM-PMS-treated rats, whereas treatment with ACTH failed to overcome the DXM inhibitory effect. These findings are interpreted to indicate that DXM inhibits ovulation through a mechanism which might involve the central nervous system. |
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