| N-正丁基-苯甲酰-2-磺酰内亚胺促渗效果的研究 |
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| 引用本文： | 姜国华,刘忠敏.N-正丁基-苯甲酰-2-磺酰内亚胺促渗效果的研究[J].北京师范大学学报(自然科学版),1998(4). |
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| 作者姓名： | 姜国华 刘忠敏 |
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| 作者单位： | 北京师范大学分析测试中心!100875，北京 |
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| 摘 要： | N-正丁基-苯甲酰-2-磺酰内亚胺是一种新型促渗剂，具有毒性小促渗效果好等特点．用=4％N-正丁基-苯甲酰-2-磺酰内亚胺处理小鼠皮肤可使皮肤给药的小檗碱血药浓度大幅度提高（生物利用度可提高11．56倍）．目前国内外常用的促渗剂氮酮只能提高生物利用度3.86倍，N-正丁基-苯甲酰-2-磺酰内亚胺的促渗效果是氮酮的2．99倍．在进行N-正丁基-苯甲酰-2-磺酰内亚胺和红细胞作用的实验时，也观察到可以引起细胞溶血，且存在时间效应和剂量效应．
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| 关 键 词： | N-正丁基-苯甲酰-2-磺酰内亚胺 促渗作用 小檗碱 溶血作用 |
A STUDY THE PENETRATION ENHANCING EFFECT OF NEW SKIN PENETRATION ENHANCER N-n-BUTYL-BENZOYL-2-SULPHIMIDE |
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| Jiang Guohua, Liu Zhongmin.A STUDY THE PENETRATION ENHANCING EFFECT OF NEW SKIN PENETRATION ENHANCER N-n-BUTYL-BENZOYL-2-SULPHIMIDE[J].Journal of Beijing Normal University(Natural Science),1998(4). |
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| Authors: | Jiang Guohua Liu Zhongmin |
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| Abstract: | N-n-butyl-benzoyl-2-sulphimide is a new skin penetration enhancer. It has less toxity and better penetration enhancing effect. It may mew blood drug concentration of Berberin and increase bioavailablity by 11.56 fold to bet de skin with N-n-butyl -benzoyl-2-sulpimide. Penehation enhancing effect of N-n-buty-benzoyl-2-sulphimide is 2.99 times of that from Azone which was used extensively. N-n-butyl-benzoyl-2-sulphimide may cause hemolysis of erythrocyte. The hemolysis is time-dependent and dose-dependent. |
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| Keywords: | N-n-butyl-benzoyl-2-sulphinde penetration enhancing effect Berberine hemoysis |
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