| 8,8—二聚代—2—氧杂双环[3.2.1]—辛—3—酮类化合物的合成 |
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| 引用本文： | 曹玉蓉,何巍.8,8—二聚代—2—氧杂双环[3.2.1]—辛—3—酮类化合物的合成[J].南开大学学报,2000,33(1):53-57. |
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| 作者姓名： | 曹玉蓉 何巍 |
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| 作者单位： | 南开大学化学系!天津，300071，南开大学化学系!天津，300071，南开大学化学系!天津，300071，南开大学化学系!天津，300071 |
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| 摘 要： | 以２－甲基－１，３－环戊二酮为原料，经过烷基化，Ｗｉｔｔｉｇ－Ｈｏｒｎｅｒ反应，催化氢化，硼氢化钠还原，酸催化下分子内酯交换反应，合成了相应的双环内酯。共十门个化合物，其中十二个未见报道。通过ＩＲ，＾１ＮＨＭＲ，元素分析或质谱分析确定了化合物的结构。通过＾１ＮＨＭＲ确定了６个顺反异构体的构型。
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| 关 键 词： | 二取代 环戊二酮 双环内酯 氧杂双环辛酮 合成 |
| 修稿时间： | 1998-12-07 |
SYNTHESIS
OF 8,8-DISUBSTITUTED-2-OXABICYCLO |
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| Cao Yurong,He Wei,Hu Zhong,Ge Chengsheng.SYNTHESIS
OF 8,8-DISUBSTITUTED-2-OXABICYCLO[J].Acta Scientiarum Naturalium University Nankaiensis,2000,33(1):53-57. |
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| Authors: | Cao Yurong He Wei Hu Zhong Ge Chengsheng |
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| Abstract: | Using 2 methyl cyclopentane 1,3 dione as start material, the title bicyclolactone was synthesized via alkylation, Wittig Horner reaction, catalytic hydrogenation, sodium borohydride reduction and acid catalyzed intramolecular transesterification. Total sixteen compounds wre synthesized, twelve of which haven't been reported. The structures of all compounds were determined by IR, 1HNMR, element analysis or mass analysis. The configuration of six geometric isomers were determined by 1HNMR. |
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| Keywords: | disbtituted cyclopentane 1 3 dione Wittig Horner reaction bicyclolactone |
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