| 毕氏酵母细胞循环模型及实验验证 |
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| 引用本文： | 贾林,袁景淇.毕氏酵母细胞循环模型及实验验证[J].上海交通大学学报,2007,41(1):108-110,115. |
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| 作者姓名： | 贾林 袁景淇 |
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| 作者单位： | 1. 上海交通大学,自动化系,上海,200240
2. 上海交通大学,自动化系,上海,200240;华东理工大学,生物反应器工程国家重点实验室,上海,200237 |
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| 摘 要： | 基于芽殖酵母细胞形态的特征,提出了毕氏酵母甘油流加发酵过程的细胞循环模型.模型的输入为比生长速率,由宏观动力学模型得到.通过细胞循环模型,求得与细胞循环过程相关的变量,如细胞带芽分率和细胞数目浓度.实验验证了模型的有效性.
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| 关 键 词： | 毕氏酵母 细胞循环模型 流加发酵 比生长速率 |
| 文章编号： | 1006-2467（2007）01-108-03 |
| 修稿时间： | 2005-11-16 |
A Cell Cycle Model of P. pastoris and Experimental Validation |
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| JIA Lin,YUAN Jing-qi.A Cell Cycle Model of P. pastoris and Experimental Validation[J].Journal of Shanghai Jiaotong University,2007,41(1):108-110,115. |
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| Authors: | JIA Lin YUAN Jing-qi |
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| Institution: | 1. Dept. of Automation, Shanghai Jiaotong Univ. , Shanghai 200240, China; 2. State Key Lab. of Bioreactor Eng. , ECUST, Shanghai 200237, China |
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| Abstract: | Based on the morphological characteristics of budding yeast,a cell cycle model during the(P.pastoris) fed-batch cultivation was proposed.The input of the cell cycle model is the specific growth rate,which is obtained from the kinetic model proposed earlier.With the cell cycle model,the cell cycle related variables,such as fraction of budding cells(FBC) and cell number density,can be simulated.Model validation is then carried out with experimental data. |
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| Keywords: | P pastoris cell cycle model fed-batch cultivation specific growth rate |
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