| 螺[二氢吲哚-3,4-吡喃]衍生物的合成与晶体结构表征 |
| |
| 引用本文： | 王倩,;吴楠,;贺玲,;徐洲,;朱松磊. 螺[二氢吲哚-3,4-吡喃]衍生物的合成与晶体结构表征[J]. 江南学院学报, 2014, 0(3): 349-354 |
| |
| 作者姓名： | 王倩, 吴楠, 贺玲, 徐洲, 朱松磊 |
| |
| 作者单位： | [1]徐州医学院基础学院,江苏徐州221004; [2]中国人民解放军空军勤务学院航空油料物资系,江苏徐州221000; [3]徐州医学院公共教育学院,江苏徐州221116 |
| |
| 基金项目： | 江苏省高校自然科学基金项目（10KJB150018）;江苏省有机合成重点实验室开放课题项目（2010JSK15）. |
| |
| 摘 要： | 以靛红、丙二腈、苯甲酰乙酸乙酯为原料,以水作溶剂,采用三乙基苄基氯化铵（TEBAC）为相转移催化剂,合成得到螺[吲哚-3,4-吡喃]衍生物C22H17N3O4.其结构通过单晶X射线衍射法确定,晶体属三斜晶系,空间群P-1,相对分子质量Mr=387.39,晶胞参数a=0.897 48 （14） nm,b =0.959 06（16）nm,c=1.106 17（19） nm,V=0.9368（3） nm^3,Z=2,晶胞密度Dc=1.373mg/m^3,吸收系数μ=0.097 mm-1,单胞中电子的数目F（000）=404.晶体结构用直接法解出,经全矩阵最小二乘法对原子参数进行修正,最终偏离因子R=0.035 9,ωR=0.089 8.在晶体结构中新形成的吡喃杂环近似于平面结构.
|
| 关 键 词： | 螺 靛红 合成 晶体结构 |
Synthesis and Crystal Structure of Spiro [indoline-3,4-pyran] Derivative |
| |
| Affiliation: | WANG Qian,WU Nan,HE Ling,XU Zhou,ZHU Songlei( 1.School of Basic Medical Sciences,Xuzhou Medical College,Xuzhou 221004,China; 2.Department of Aviation POL and Materials,P O L Air Force Logistic College,Xuzhou 221000, China; 3.School of Basic Education Sciences, Xuzhou Medical College, Xuzhou 221004, China) |
| |
| Abstract: | The Ethyl 2-amino-3-cyano-2-oxo-6-phenylspiro[indoline-3,4-pyran]-5-carboxylate has been synthesized by the reaction of isatin,malononitrile,benzoylacetate and TEBAC as phase transfer catalyst in H2O at 60 ℃.The structure of the product was determined by single crystal X-ray diffraction.The crystal is triclinic,space group P-1,with Mr =387.39,a =0.897 48 （14）nm,b =0.959 06 （16）nm,c =1.106 17 （19）nm,V =0.936 8 （3） nm3,Z =2,Dc =1.373 mg/m3,μ =0.097 mm-1,F（000） =404.The structure was solved by direct methods and refined by full-mat rix least squares method to the final R =0.035 9,ωR =0.089 8.X-ray analysis reveals that the formation of new pyran ring in the crystal structure is a planar structure. |
| |
| Keywords: | spiro isatin synthesis crystal structure |
| 本文献已被 维普 等数据库收录！ |
|
