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Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma |
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| Authors: | Milada Stuchlová Horynová Milan Ra?ka Henrik Clausen Jan Novak |
| Institution: | 1. Department of Immunology, Faculty of Medicine and Dentistry, Palacky University, Hněvotínská 3, 77515, Olomouc, Czech Republic 4. Department of Microbiology, University of Alabama at Birmingham, 845 19th St. S., BBRB 762, Birmingham, AL, 35294, USA 3. Center for Glycomics, Departments of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen N, Denmark 2. Department of Microbiology, University of Alabama at Birmingham, 845 19th St. S., BBRB 761A, Birmingham, AL, 35294, USA |
| Abstract: | Glycosylation abnormalities have been observed in autoimmune diseases and cancer. Here, we compare mechanisms of aberrant O-glycosylation, i.e., formation of Tn and sialyl-Tn structures, on MUC1 in breast cancer, and on IgA1 in an autoimmune disease, IgA nephropathy. The pathways of aberrant O-glycosylation, although different for MUC1 and IgA1, include dysregulation in glycosyltransferase expression, stability, and/or intracellular localization. Moreover, these aberrant glycoproteins are recognized by antibodies, although with different consequences. In breast cancer, elevated levels of antibodies recognizing aberrant MUC1 are associated with better outcome, whereas in IgA nephropathy, the antibodies recognizing aberrant IgA1 are part of the pathogenetic process. |
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