Estimation of the methylating capacity in the pineal gland of the rat with special reference to the methylation of N-acetylserotonin and 5-hydroxytryptophol separately

Summary In the present paper, an extension is presented of an earlier described method, by which the methylating capacity of the pineal gland can be determined. Supplementary to the earlier method, the synthesis of melatonin and 5-methoxytryptophol can now be qualified and quantified separately.The authors wish to express their gratitude to Prof. Dr J.C. van de Kamer and Dr F.C.G. van de Veerdonk for their stimulating interest in these studies.