Formation of lipoperoxide in isolated sciatic nerve by chinoform-ferric chelate |
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| Authors: | Y Yagi M Matsuda K Yagi |
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| Institution: | (1) Department of Biochemistry, Jikei University School of Medicine, 105 Tokyo, (Japan);(2) Present address: Institute of Biochemistry, Faculty of Medicine, University of Nagoya, 466 Nagoya, (Japan) |
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| Abstract: | Summary Effects of chinoform and chinoform-ferric chelate on formation of lipoperoxide in isolated sciatic nerve were investigated. Free chinoform did not increase the lipoperoxide level, while chinoform-ferric chelate significantly increased it. Assuming that the lipoperoxide formed denatures the associated protein in the nerve, the effect of chinoform-ferric chelate could explain, at least partly, the demyelination of nerve tissues caused by massive doses of chinoform. |
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