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应力方向对内皮细胞力学传递和功能的影响
引用本文:钱煦.应力方向对内皮细胞力学传递和功能的影响[J].北京大学学报(自然科学版),2007,43(4):435-440.
作者姓名:钱煦
作者单位:美国加州大学圣地亚哥分校生物工程系,医学系和辉迪格生物医学工程研究院, 圣地亚哥,92093-0412
基金项目:国家高技术研究发展计划(863计划)
摘    要:剪切力可经由应力感受、信息传递和基因与蛋白质的表达来调控血管内皮细胞的功能。层流剪切力会导致单核细胞趋化蛋白质(MCP-1)及多种增生基因的迅速上调。但有特定方向的持久层流剪切力会使MCP-1及增生基因与蛋白下调, 同时并上调抑制内皮细胞增生的基因与蛋白。复杂的流型没有什么固定的方向,会使MCP-1及增生基因持续上调,因而增加单核细胞的侵入及内皮细胞的分裂及凋亡。在动脉的直管部分,层流剪切力有特定的方向,因此有抗动脉粥样硬化的作用。在动脉分支部位,复杂的流型有促使动脉粥样硬化的作用。所以,应力的方向对内皮细胞在正常及疾病时的功能有重要影响。

关 键 词:粥样硬化  基因表达  整合素  剪切力  信息传递  
收稿时间:2007-04-11
修稿时间:2007-04-11

Role of Stress Direction on Mechanotransduction and Functions of Endothelial Cells
CHIEN Shu.Role of Stress Direction on Mechanotransduction and Functions of Endothelial Cells[J].Acta Scientiarum Naturalium Universitatis Pekinensis,2007,43(4):435-440.
Authors:CHIEN Shu
Institution:Departments of Bioengieering and Medicine, and the Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla, CA 92093-0412, U.S.A.
Abstract:Shear stress can regulate vascular endothelial cell(EC)functions through membrane sensing,intracellular signal transduction,and modulation of gene and protein expressions.Laminar shear stress causes transient increases in the expressions of MCP-1 and the genes and proteins that upregrulate proliferation of ECs.The continued application of such shear flow with a definitive direction,however,causes the down-regulation of these molecules and the up-regulation of genes and proteins that inhibit growth.Complex flow pattern that does not have a definitive direction causes sustained increases of MCP-1 and the genes and proteins that stimulate proliferation,thus enhancing the invasion of monocytes and the turnover of ECs.In the straight part of the arterial tree,laminar flow prevails and has anti-atherogenic effects.In contrast,the disturbed flow at branch points does not have a specific direction and is atherogenic.Therefore,the directionality of shear stress plays an important role in regulation of EC functions in health and disease.
Keywords:atherosclerosis  gene expression  integrins  shear stress  signal transduction
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