| 一种新的氧哌嗪合成路线 |
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| 引用本文： | 王永亮,庞先勇. 一种新的氧哌嗪合成路线[J]. 太原理工大学学报, 2007, 38(1): 26-27 |
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| 作者姓名： | 王永亮 庞先勇 |
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| 作者单位： | 太原理工大学,化学工程与技术学院,山西,太原,030024 |
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| 摘 要： | 在对一些采用氧哌嗪合成路线进行分析比较的基础上,以乙二胺与溴乙烷为原料制备N-乙基乙二胺,经环合,酰氯化(改进),生成双氧哌嗪酰氯与氨苄三水酸缩合得氧哌嗪酸,该方法具有路线简单,成本低,产品纯度高,对操作条件要求较宽等特点,且收率高,达到96.0%。
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| 关 键 词： | 氧哌嗪 酰氯化 合成 |
| 文章编号： | 1007-9432（2007）01-0026-02 |
| 收稿时间： | 2006-05-26 |
| 修稿时间： | 2006-05-26 |
New Improvement for the Preparation of Piperacillin Sodium |
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| WANG Yong-liang,PANG Xian-yong. New Improvement for the Preparation of Piperacillin Sodium[J]. Journal of Taiyuan University of Technology, 2007, 38(1): 26-27 |
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| Authors: | WANG Yong-liang PANG Xian-yong |
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| Abstract: | Based on comparing and analyzingtoformer preparationroutes,this article promi-nently reported that the i mprovent of prosess for preparing n-ethyle-2,3-dioxo-1-piperazine car-bonychloride fromethylenediamine and ethyl chloride by cycization,acetyl chlorination(i mprove),then reacted with ampicillinto give piperacillin and salted with bicarbonate sodium,thentofreeze-drying.This routeis not only si mple but also cheap.In addition,the purity and productive per-cent is high(96.0 %),and the productive conditionis suit to manipulate. |
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| Keywords: | piperacillin sodium chlorination synthesis |
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