| 研究蒺藜总皂甙对家兔急性心肌梗塞治疗作用的机理 |
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| 引用本文： | 赵淑文,任庆林,范心田,阵建光,高振芳,董文春,靳桂英,刘淑玲,孙国权,唐利民. 研究蒺藜总皂甙对家兔急性心肌梗塞治疗作用的机理[J]. 北华大学学报(自然科学版), 1994, 0(1) |
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| 作者姓名： | 赵淑文 任庆林 范心田 阵建光 高振芳 董文春 靳桂英 刘淑玲 孙国权 唐利民 |
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| 作者单位： | 吉林医学院药理教研室(赵淑文，任庆林，范心田，阵建光)，吉林医学院卫生科(高振芳)，吉林医学院附属医院(董文春)，吉林省肿瘤医院药剂科(靳桂英，刘淑玲，孙国权)，吉林省肿瘤医院药剂科(唐利民) |
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| 摘 要： | 实验采用结扎家兔冠状动脉左前降支造成急性心肌梗塞(Acute myocardialinfarction,AMI)再灌注后损伤动物模型,研究蒺藜总皂甙(Tribulus terrestis L saponin,TTLS)对AMI治疗作用机理。实验结果表明,和普萘洛尔的作用相同,不同剂量TTLS均能明显保护超氧化物岐化酶(Superoxide dismutases,SOD)的活性,和能明显减少丙二醛(Malondialdehede,MDA)的含量,二者呈高度负相关。这些实验结果提示,TTLS对家兔急性心肌梗塞的治疗作用机理在于保护SOD的活性和减少MDA的含量,为临床治疗提供了客观的实验依据。
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| 关 键 词： | 蒺藜总皂甙 急性心肌梗塞 氧自由基 超氧化物岐化酶 丙二醛 |
Experimental Study on the Mechanism of TTLS for the treatment on Rabbits with AMI |
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| Zhao Shu Wen,et al. Experimental Study on the Mechanism of TTLS for the treatment on Rabbits with AMI[J]. Journal of Beihua University(Natural Science), 1994, 0(1) |
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| Authors: | Zhao Shu Wen et al |
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| Abstract: | In our study,the animal models of AMI were made by using the method of ligat-ing the left anterior descending coronary artery of rabbit to observe the therapeutic effects of TTLS on AMI of rabbits. The results showed that TTLS reduced MDA(Malondialdehyde)con-tent significantly,and The effect was also dose dependent the same as propranolol. It is believed that the mechanism effect of curative effect of TTLS on AMI of rabbit was closely related to increasing SOD and decreasing MDA,and that the results obtained provide an experimental basis for clinical treatment of patient with AMI. |
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| Keywords: | TTLS AMI OFR SOD MDA |
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