| 盐酸坦洛新渗透泵片的研制及释药影响因素考察 |
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| 引用本文： | 夏志国,马忠朝,陈文波.盐酸坦洛新渗透泵片的研制及释药影响因素考察[J].浙江海洋学院学报(自然科学版),2007,26(4):435-438. |
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| 作者姓名： | 夏志国 马忠朝 陈文波 |
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| 作者单位： | 海力生集团有限公司研究所,浙江舟山,316021 |
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| 摘 要： | 目的:制备低剂量的盐酸坦洛新单室渗透泵型控释片,并考察其释药机理及影响释药因素。方法:单因素考察影响释药因素。结果:制备了低剂量的难溶性酸坦洛新单室渗透泵型控释片;氯化钠、衣膜厚度及致孔剂的用量是影响释药的主要因素。结论:盐酸坦洛新单室渗透泵型片工艺稳定,能够达到12h明显的恒速释药。
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| 关 键 词： | 盐酸坦洛新 控释片 释药因素 单室渗透泵 |
| 文章编号： | 1008-830X（2007）04-0435-04 |
| 收稿时间： | 2007-09-16 |
| 修稿时间： | 2007年9月16日 |
A Study of Preparation and the Factors Influencing Mechanism of Drug Release Tamsulosin Hydrochloride Osmotic Pump Tablets |
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| XIA Zhi-guo,MA Zhong-chao,CHEN Wen-bo.A Study of Preparation and the Factors Influencing Mechanism of Drug Release Tamsulosin Hydrochloride Osmotic Pump Tablets[J].Journal of Zhejiang Ocean University(Natural Science Edition),2007,26(4):435-438. |
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| Authors: | XIA Zhi-guo MA Zhong-chao CHEN Wen-bo |
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| Abstract: | Aim: to investigate the preparation and factors of the release mechanism of low dose tamsulosin hydrochloride Elementary osmotic pump controlled release tablets.Methods: The optimal formulation and the factor influencing the drug release was selected by the single factor investigation.Results: prepared tamsulosin hydrochloride elementary osmotic pump-controlled release tablets.Results: the formulation of sodium chloride and the coating membrane thickness and the amount of poremaking agent showed marked effects on drug release.Conclusions: the process conditions of tamsulosin hydrochloride Elementary osmotic pump-controlled release tablets is stable,reached obvious Steady release Speed in 12 hours. |
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| Keywords: | tamsulosin hydrochloride controlled release tablets release factor elementary osmotic pump |
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