Fate choice of post-natal mesoderm progenitors: skeletal versus cardiac muscle plasticity |
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Authors: | Domiziana Costamagna Mattia Quattrocelli Robin Duelen Vardine Sahakyan Ilaria Perini Giacomo Palazzolo Maurilio Sampaolesi |
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Institution: | 1. Translational Cardiomyology Lab, Department of Development and Regeneration, Stem Cell Institute Leuven, Embryo and Stem Cell Biology, KU Leuven, Herestraat 49, O&N4, Bus 814, 3000, Leuven, Belgium
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Abstract: | Regenerative medicine for skeletal and cardiac muscles still constitutes a fascinating and ambitious frontier. In this perspective, understanding the possibilities of intrinsic cell plasticity, present in post-natal muscles, is vital to define and improve novel therapeutic strategies for acute and chronic diseases. In addition, many somatic stem cells are now crossing the boundaries of basic/translational research to enter the first clinical trials. However, it is still an open question whether a lineage switch between skeletal and cardiac adult myogenesis is possible. Therefore, this review focuses on resident somatic stem cells of post-natal skeletal and cardiac muscles and their plastic potential toward the two lineages. Furthermore, examples of myogenic lineage switch in adult stem cells are also reported and discussed. |
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