| 荜茇酰胺的合成及生物活性研究进展 |
| |
| 引用本文： | 陆芳柳,庄春林,缪震元,张万年,吴岳林. 荜茇酰胺的合成及生物活性研究进展[J]. 上海应用技术学院学报：自然科学版, 2017, 17(4): 309-316 |
| |
| 作者姓名： | 陆芳柳 庄春林 缪震元 张万年 吴岳林 |
| |
| 作者单位： | 上海应用技术大学 化学与环境工程学院, 上海 201418,第二军医大学 药学院, 上海 200433,第二军医大学 药学院, 上海 200433,第二军医大学 药学院, 上海 200433,上海应用技术大学 化学与环境工程学院, 上海 201418 |
| |
| 基金项目： | 青年教师培养资助计划(ZZyy15096);上海应用技术大学引进人才基金(YJ2015-12)资助 |
| |
| 摘 要： | 荜茇酰胺是一种具有多种生物活性的天然生物碱,其药理活性包括抗肿瘤、抗血小板凝集、抗抑郁和抗焦虑等。近年来,对其抗肿瘤活性研究较多,其最大的特点是对多种肿瘤细胞具有特异性的细胞毒作用,而对正常细胞无影响。综述了荜茇酰胺的化学合成方法、药理作用以及构效关系的研究。
|
| 关 键 词： | 荜茇酰胺 化学合成 生物活性 构效关系 |
| 收稿时间： | 2017-04-12 |
Synthesis and Biological Activities of Piperlongumine |
| |
| LU Fangliu,ZHUANG Chunlin,MIAO Zhenyuan,ZHANG Wannian and WU Yuelin. Synthesis and Biological Activities of Piperlongumine[J]. Journal of Shanghai Institute of Technology: Natural Science, 2017, 17(4): 309-316 |
| |
| Authors: | LU Fangliu ZHUANG Chunlin MIAO Zhenyuan ZHANG Wannian WU Yuelin |
| |
| Affiliation: | School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China,School of Pharmacy, Second Military Medical University, Shanghai 200433, China,School of Pharmacy, Second Military Medical University, Shanghai 200433, China,School of Pharmacy, Second Military Medical University, Shanghai 200433, China and School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China |
| |
| Abstract: | Piperlongumine is a natural alkaloid with many pharmacological activities, including anticancer, antiplatelet aggregation, anti-depression and antianxiety. Recently, the anticancer activity of piperlongumine has been studied intensively due to its specific cytotoxic effect towards tumor cells and non-cytotoxicity towards normal cells. The synthesis, biological activities and structure-activity relationships of piperlongumine derivatives were reviewed in this article. |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《上海应用技术学院学报：自然科学版》浏览原始摘要信息 |
|
点击此处可从《上海应用技术学院学报：自然科学版》下载全文 |
|
