| 钯催化不对称氢化反应和氢解反应 |
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| 引用本文： | 陈建中,张万斌. 钯催化不对称氢化反应和氢解反应[J]. 上海应用技术学院学报：自然科学版, 2017, 17(1): 85-88 |
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| 作者姓名： | 陈建中 张万斌 |
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| 作者单位： | 上海交通大学 化学化工学院,上海 20024,上海交通大学 化学化工学院,上海 20024 |
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| 基金项目： | 国家自然科学基金资助项目(No. 21232004, 21620102003)；上海市科委基金资助项目(No. 14XD1402300, 15JC1402200, 17ZR1415200) |
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| 摘 要： | 实现了α-酰氧基芳基酮的化学选择性和对映选择性氢化及氢解反应,分别得到重要的手性二醇单酯、简单酮和手性α-酰氧基芳基酮.手性产物经过衍生,可应用于多种具有生物活性的天然产物和药物的合成中.该催化反应的底物与催化剂比例(S/C)可高达5 000~6 000,证明了均相钯催化氢化具有工业应用前景.
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| 关 键 词： | 钯催化 不对称氢化 对映选择性 氢解 α-酰氧基芳基酮 |
| 收稿时间： | 2017-03-15 |
| 修稿时间： | 2017-03-15 |
Palladium-Catalyzed Chemo- and Enantioselective Hydrogenation and Hydrogenolysis |
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| Abstract: | This paper briefly introduces recent progress our group has made in the area of Pd-catalyzed asymmetric hydrogenation and hydrogenolysis. A Palladium catalyzed chemo- and enantioselective hydrogenation and hydrogenolysis of a-acyloxy ketones for the synthesis of chiral a-acyloxy-1-arylethanols, simple ketones and chiral a-acyloxy ketones, has been reported for the first time. The chiral products have the potential to be transformed to various biologically active compounds and chiral drugs. Of note is that S/C ratios up to 5000-6000 were obtained, suggesting that this homogeneous palladium catalyzed asymmetric hydrogenation has good prospects for use in industry. |
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| Keywords: | palladium catalysis asymmetric hydrogenation enantioselectivity hydrogenolysis a-acyloxy ketones |
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