干扰素诱导的IFI-200蛋白家族研究进展

IFI-200蛋白家族是一组高度保守的干扰素诱导蛋白,家族中的每个成员其C-末端含有一个或几个特征性200氨基酸结构域.到目前为止,已发现有10个IFI-200蛋白家族成员,其中6个成员来源于小鼠,包括p202a、p202b、p203、p204、p205和p206,另外4个成员来源于人体,分别是IFI16、MNDA、AI M2和IFIX.IFI-200蛋白家族成员已知参与细胞生长、细胞衰老、细胞分化及细胞死亡的调控.但是,最近愈来愈多的证据显示IFI-200家族成员在人类肿瘤及自身免疫疾病中起作用.

The Study Progress of the Interferon-Inducible IFI-200 Protein Family

IFI-200 protein family is a group of highly conserved interferon-inducible proteins, each of which contains one or several characteristic 200 amino acid domains at its C-terminal. At present, ten members bare already been found in the IFI-200 protein family. Among them, six members are from mice, including p202a, p202b, p203, p204, p205 and p206. And four other members are from humans, which are IFII6, MNDA, AIM2 and IFIX. IFI-200 family members have been known to be involved in the regulation of cell growth, cell senescence, cell differentiation and cell death. But recently, more and more evidences showed IFI-200 family members play roles in human cancers and autoimmune diseases.