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Gonyauline: A novel endogenous substance shortening the period of the circadian clock of a unicellular alga |
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| Authors: | T. Roenneberg H. Nakamura L. D. Cranmer III K. Ryan Y. Kishi J. W. Hastings |
| Affiliation: | (1) Department of Cellular and Developmental Biology, Harvard University, 02138 Cambridge, Massachusetts, USA;(2) Department of Chemistry, Harvard University, 02138 Cambridge, Massachusetts, USA;(3) Present address: Medizinische Psychologie, Universität München, Goethestrasse 31, D-8000 München, Germany;(4) Present address: Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, Japan |
| Abstract: | Summary The circadian clock in the unicellular algaGonyaulax polyedra is accelerated by a substance in extracts from the cells themselves. The extracts have been fractionated using the circadian rhythm of bioluminescence as bioassay. The active substance, termed gonyauline, has been isolated and characterized as a novel low molecular weight cyclopropanecarboxylic acid (S-methyl-cis-2-(methylthio) cyclopropanecarboxylic acid). Synthetic gonyauline has a similar shortening effect on the period of the circadian clock. |
| Keywords: | Circadian rhythm period length creatine S-methyl-cis-2-(methylthio) cyclopropanecarboxylic acid Gonyaulax polyedra |
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