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Structure and expression of a cloned cDNA for human interleukin-2 |
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| Authors: | T Taniguchi H Matsui T Fujita C Takaoka N Kashima R Yoshimoto J Hamuro |
| Abstract: | A cDNA coding for human interleukin-2 (IL-2) has been cloned from a cDNA library prepared from partially purified IL-2 mRNA. The DNA sequence codes for a polypeptide which consists of 153 amino acids including a putative signal sequence. A biologically active polypeptide, characteristic of human IL-2, was produced when the cDNA was fused to a simian virus 40 promoter sequence and used to transfect cultured monkey COS cells. |
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