Ornithine decarboxylase,S-adenosyl-L-methionine decarboxylase and arginine decarboxylase fromMycobacterium bovis (BCG) |
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Authors: | L. Paulin E. Brander H. Pösö |
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Affiliation: | (1) Department of Pharmacology and Toxicology, College of Veterinary Medicine, SF-00550 Helsinki, Finland;(2) National Public Health Institute, SF-00280 Helsinki, Finland |
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Abstract: | Summary Ornithine decarboxylase (ODC), S-adenosyl-L-methionine decarboxylase (AMDC) and arginine decarboxylase (ADC) activities were detected for the first time in extracts ofMycobacterium bovis (BCG). All the decarboxylases differed from corresponding known bacterial decarboxylases in that: a) ODC did not require GTP for activity; b) ODC was not inhibited by any known inhibitor of bacterial ODCs; c) AMDC and ADC did not require Mg2+-ion for activity and were not markedly inhibited by any known inhibitor of the decarboxylases of other bacteria. |
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Keywords: | Polyamine biosynthesis Mycobacterium bovis (BCG) inhibition of polyamine biosynthesis |
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