Possible regulation of membrane-associated cyclic AMP phosphodiesterase in rat cerebral cortex by lipids |
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| Authors: | A Baba T Tsukamoto T Matsuda H Iwata |
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| Institution: | (1) Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, 133-1, Yamada-kami, 565 Suita-shi, Osaka, (Japan) |
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| Abstract: | Summary Cyclic AMP phosphodiesterase (PDE) in membrane fraction from rat cerebral cortex was activated by Triton X-100, and treatment at alkaline pH and with phospholipase C. These results suggest that membrane PDE exists in a latent form and is influenced by microenvironmental changes within the membrane. Furthermore, the PDE, unlike soluble enzyme, is not influenced by a protein activator and Ca++. |
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