The effect of cyclic AMP on dog renal function

Summary The infusion of dibutyryl-cyclic AMP into the dog renal artery in vivo leads to diuresis, natriuresis and glucosuria. Addition of the nucleotide to the incubation medium bathing dog renal cortex slices in vitro causes inhibition of p-amino-hippurate accumulation and stimulation of glycine and -methyl-glucoside transport. The results are interpreted in terms of the development of a blood-lumen flux of sodium and water in the renal proximal tubule, analogous to that seen in the intestine.We are grateful to Mrs P. Ganguillet, S. Henriot, Miss M. Augstburger and D. Mettraux technical skilful technical assistance, and to the Fonds National Suisse for financial support.