Kompensation der teratogenen Wirkung eines Thalidomid-Metaboliten durchl-Glutaminsäure |
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Authors: | F. Köhler H. Ockenfels |
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Affiliation: | (1) Institut für Humangenetik der Universität Bonn, Wilhelmsplatz 7, D-53 Bonn, Deutschland;(2) Abteilung für Biochemie der Universität Ulm, Parkstrasse 11, D-69 Ulm, Deutschland |
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Abstract: | Summary Skeletal defects were observed in the off-spring of SWS-mice following i.p. administration of phthaloyl-l-glutamic acid, a metabolite of thalidomide. The fetuses of animals which receivedl-glutamic acid in addition to the teratogenic drug, did not show any malformations, whereas concurrent i.p. administration of thed-isomer of glutamic acid failed to reverse teratogenicity induced by phthaloyl-l-glutamic acid. |
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