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| 血清microRNA在肿瘤诊断和预后评估中的应用 | |
| 引用本文： | 许建,武治印,于典科.血清microRNA在肿瘤诊断和预后评估中的应用[J].科学通报,2010,55(1):2-6. |
| 作者姓名： | 许建 武治印 于典科 |
| 作者单位： | ① 中国医学科学院肿瘤研究所病因及癌变研究室, 北京 100021; ② 中国生物技术发展中心, 北京 100036 |
| 摘 要： | 介绍了血清microRNA与肿瘤发生的关系, 并且在此基础上系统介绍了国内外将血清microRNA作为肿瘤标志物的研究进展. 尽管血清microRNA作为肿瘤的分子标志物尚有许多问题要解决, 但目前的研究结果已经证明血清microRNA表达谱的变化与多种肿瘤的发生、发展具有明确的相互关系, 说明血清microRNA可以作为肿瘤临床诊断和预后评估的分子标志物. 而且, 血清microRNA自身的特性也决定了其在应用于肿瘤临床诊断和预后评估时具有创伤小、技术快速、便捷等优点. |
| 关 键 词： | 肿瘤标志物 血清microRNA 诊断 预后 |
| 收稿时间： | 2009-07-15 |
| 修稿时间： | 2009-08-22 |
Serum microRNA and its applied prospect in tumor diagnosis and prognosis |
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| XU Jian,WU ZhiYin & YU DianKe.Serum microRNA and its applied prospect in tumor diagnosis and prognosis[J].Chinese Science Bulletin,2010,55(1):2-6. | |
| Authors: | XU Jian WU ZhiYin & YU DianKe |
| Institution: | 1 Department of Etiology & Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China; 2 China National Center for Biotechnology Development, Beijing 100036, China |
| Abstract: | The aim of this paper is to introduce the relationship of the serum microRNAs and carcinogenesis and the progress of the serum microRNAs as the potential clinical biomarkers of various cancers. Though much difficulty remains in the serum microRNAs studies, more evidences indeed proved the associations between the serum microRNA profiles and the carcinogenesis. Moreover, the serum microRNAs detection is low-invasive and easy to handle, indicating the serum microRNAs might to be useful biomarkers for tumor diagnosis or prognosis. |
| Keywords: | tumor biomarker serum microRNA diagnosis prognosis |
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