Efficient delivery of siRNA for inhibition of gene expression in postnatal mice |
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| Authors: | Lewis David L Hagstrom James E Loomis Aaron G Wolff Jon A Herweijer Hans |
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| Institution: | Mirus Corporation, 505 South Rosa Road, Madison, Wisconsin 53719, USA. davel@genetransfer.com |
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| Abstract: | It has recently been shown that RNA interference can be induced in cultured mammalian cells by delivery of short interfering RNAs (siRNAs). Here we describe a method for efficient in vivo delivery of siRNAs to organs of postnatal mice and demonstrate effective and specific inhibition of transgene expression in a variety of organs. |
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