Microbial thermosensors |
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Authors: | Birgit Klinkert Franz Narberhaus |
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Affiliation: | 1. Lehrstuhl für Biologie der Mikroorganismen, Ruhr-Universit?t Bochum, Universit?tsstrasse 150, NDEF 06/783, 44780, Bochum, Germany
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Abstract: | Temperature is among the most important of the parameters that free-living microbes monitor. Microbial physiology needs to be readjusted in response to sudden temperature changes. When the ambient temperature rises or drops to potentially harmful levels, cells mount protective stress responses—so-called heat or cold shock responses, respectively. Pathogenic microorganisms often respond to a temperature of around 37°C by inducing virulence gene expression. There are two main ways in which temperature can be measured. Often, the consequences of a sudden temperature shift are detected. Such indirect signals are known to be the accumulation of denatured proteins (heat shock) or stalled ribosomes (cold shock). However, this article focuses solely on direct thermosensors. Since the conformation of virtually every biomolecule is susceptible to temperature changes, primary sensors include DNA, RNA, proteins and lipids. |
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Keywords: | Heat shock Cold shock Temperature Sensor Thermometer Stress response Virulence Gene regulation |
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