| 2-芳基-4-戊烯基酯的“一锅法”合成 |
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| 引用本文： | 柏一慧,杜金艳. 2-芳基-4-戊烯基酯的“一锅法”合成[J]. 浙江师范大学学报(自然科学版), 2014, 0(3): 312-316 |
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| 作者姓名： | 柏一慧 杜金艳 |
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| 作者单位： | 浙江师范大学化学与生命科学学院,浙江金华321004 |
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| 摘 要： | 以α-芳基乙酰基苯并三唑和烯丙基碳酸乙酯为原料,Tsuji-Trost反应为关键步骤,通过"一锅法"操作合成了2-芳基-4-戊烯基酯,产率最高达85%.考察了催化剂、配体、溶剂等对反应的影响,确定了优化反应条件,并给出了可能的反应机理.产物经1H NMR和13C NMR分析确证.
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| 关 键 词： | -芳基--戊烯基酯 α-芳基乙酰基苯并三唑 烯丙基碳酸乙酯 Tsuji-Trost反应 钯 一锅法 |
A one-pot entry to 2-aryl-4-pentenoates |
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| BAI Yihui,DU Jinyan. A one-pot entry to 2-aryl-4-pentenoates[J]. Journal of Zhejiang Normal University Natural Sciences, 2014, 0(3): 312-316 |
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| Authors: | BAI Yihui DU Jinyan |
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| Affiliation: | ( College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua Zhejiang 321004, China) |
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| Abstract: | A one-pot synthesis of 2-aryl-4-pentenoates was realized by the Pd-catalyzed coupling of α-aryl N-acetylbenzotriazoles with allyl ethyl carbonate , followed by esterification reaction in alcohol solvents , produced yields up to 85%.The effects of catalyst , ligand and solvent on the yield were investigated .The optimum re-action conditions were determined and the possible mechanism was proposed .The products were identified by 1 H NMR and 13 C NMR.The present methodology provided several advantages such as mild reaction condition , excellent yield and environmental friendliness . |
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| Keywords: | 2-aryl-4-pentenoates α-aryl N-acetylbenzotriazoles allyl ethyl carbonate Tsuji-Trost reaction palladium one-pot |
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