| 抗细胞凋亡蛋白DAD研究进展 |
| |
| 引用本文： | 潘永娟,金晓琴,刘伟娜,徐玲玲,杨莉. 抗细胞凋亡蛋白DAD研究进展[J]. 浙江师范大学学报(自然科学版), 2014, 0(2): 212-218 |
| |
| 作者姓名： | 潘永娟 金晓琴 刘伟娜 徐玲玲 杨莉 |
| |
| 作者单位： | 浙江师范大学化学与生命科学学院,浙江金华321004 |
| |
| 基金项目： | 国家自然科学基金青年科学基金资助项目（30900978）;浙江省自然科学基金资助项目（Y3110409） |
| |
| 摘 要： | 结合国内外的研究,从抗细胞凋亡基因DAD(defender against cell death)的发现、核苷酸序列同源性、表达特性和蛋白结构与功能等方面,对近年来DAD蛋白的研究进展进行了综述.DAD作为寡聚糖转移酶(oligosaccharyltransferase,OST)的亚基组分,参与了内质网(endoplasmic reticulum,ER)中蛋白质的N-糖基化修饰,抑制程序性细胞死亡,与动植物的生长发育及多种生理与病理过程密切相关.
|
| 关 键 词： | 抗细胞凋亡蛋白 程序性细胞死亡 寡聚糖转移酶 N-糖基化 生物学功能 |
On the research progresses in defender against cell death protein |
| |
| PAN Yongjuan,JIN Xiaoqing,LIU Weina,XU Lingling,YANG Li. On the research progresses in defender against cell death protein[J]. Journal of Zhejiang Normal University Natural Sciences, 2014, 0(2): 212-218 |
| |
| Authors: | PAN Yongjuan JIN Xiaoqing LIU Weina XU Lingling YANG Li |
| |
| Affiliation: | ( College of Chemistry and Life Science, Zhejiartg Normal University, Jinhua Zhejiang 321004, China) |
| |
| Abstract: | It was overviewed the composition of the discovery,nucleotide and protein sequence homology,expression characteristics,protein structures and functions of DAD. As an essential subunit of oligosaccharyl-transferase,defender against cell death（DAD）protein was well-known as one of negative regulators of PCD, involved in N-glycan modification,as well as related to physiological and pathological processes in plants and animals. |
| |
| Keywords: | defender against cell death （ DAD） programmed cell death （ PCD） oligosaccharyhransferase（OST） .N-linked glycosylation biological functions |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
