Biliary excretion of sulfobromophthalein in isolated perfused livers from normal and spironolactone-treated rats |
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Authors: | J M Pellegrino A D Mottino J V Rodriguez E A Rodriguez Garay |
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Institution: | (1) Departamento de Fisiología, Facultad de Ciencias Bioquímicas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, (Argentina) |
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Abstract: | Summary Bile flow and biliary excretion of sulfobromophthalein (BSP) was examined in isolated perfused livers from normal and spironolactone(SP)-treated rats. BSP biliary excretion contributed to the bile production in both groups. Moreover SP increased BSP biliary excretion but transfer of dye from plasma into liver was not affected.Acknowledgments. This work was supported by a grant from Consejo Nacional de Investigaciones Científicas y Técnicas República Argentina (EFIHER-CONICET). Isolated rat liver preparations were performed by Miss Graciela Patricia Rodriguez. The assistance of Carlos Guillermo Grieve is also gratefully acknowledged. |
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