Decreased rates of Ca2+-dependent heat production in slow- and fast-twitch muscles from the dystrophic (mdx) mouse |
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| Authors: | A. Decrouy P. C. Even A. Chinet |
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| Affiliation: | (1) Departement de Physiologie, Centre Médical Universitaire, 1 rue Michel-Servet, CH-1211 Geneva 4, (Switzerland);(2) Laboratoire de Neurobiologie des Régulations, CNRS UA 637, Collège de France, 11 place Marcelin-Berthelot, F-75231 Paris Cédex 05, (France) |
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| Abstract: | Using a newly developed microcalorimetric approach to assess the rate of energy expenditure for intracellular [Ca2+] homeostasis in isolated muscles at rest, we found this was lower inmdx than in control mouse muscles, by 62% and 29% in soleus and extensor digitorum longus, respectively. Differences in total and Ca2+-dependent rates of specific heat production betweenmdx and control were enhanced during sustained, KCl-induced stimulation of energy dissipation. These results suggest that the low sacroplasmic energy status of dystrophic muscles is not due to any excessive energy expenditure for intracellular [Ca2+] homeostasis. |
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| Keywords: | Ca2+ transport energy metabolism skeletal muscle sacroplasmic reticulum Ca2+ channel sacroplasmic Ca2+ homeostasis muscular dystrophy |
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