The alpha-kinase family: an exceptional branch on the protein kinase tree |
| |
Authors: | Jeroen Middelbeek Kristopher Clark Hanka Venselaar Martijn A Huynen Frank N van Leeuwen |
| |
Institution: | (1) Laboratory of Pediatric Oncology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands;(2) MRC Protein Phosphorylation Unit, Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, UK;(3) Centre for Molecular and Biomolecular Informatics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands; |
| |
Abstract: | The alpha-kinase family represents a class of atypical protein kinases that display little sequence similarity to conventional
protein kinases. Early studies on myosin heavy chain kinases in Dictyostelium discoideum revealed their unusual propensity to phosphorylate serine and threonine residues in the context of an alpha-helix. Although
recent studies show that some members of this family can also phosphorylate residues in non-helical regions, the name alpha-kinase
has remained. During evolution, the alpha-kinase domains combined with many different functional subdomains such as von Willebrand
factor-like motifs (vWKa) and even cation channels (TRPM6 and TRPM7). As a result, these kinases are implicated in a large
variety of cellular processes such as protein translation, Mg2+ homeostasis, intracellular transport, cell migration, adhesion, and proliferation. Here, we review the current state of knowledge
on different members of this kinase family and discuss the potential use of alpha-kinases as drug targets in diseases such
as cancer. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|