立方液晶作为药物载体的研究

甘油单油酸酯(MO)，嵌段共聚物((PEO)99-(PPO)67-(PF0)99，F127)，水立方液晶体系在水中分散可形成立方液晶颗粒分散体系，该分散体系可作为药物缓释的载体、利用原子力显微镜(AFM)和动态激光光散射法测试了立方液晶颗粒的尺寸，分别用紫外分光光度法和高压液相色谱仪测定了甘油单十四烷酸酯(MM)、甘油单十六烷酸酯(MP)、F127以及不同溶剂对立方液晶颗粒包结阿司匹林或咖啡因缓释效率的影响，结果表明：分散体系中加入MP后，可提高阿司匹林的释放效率；而MM的加入则降低药物的释放效率，F127的质量分数达到一定值时，对药物缓释效率有显著的促进作用．制备前体时，使用不同的溶剂，包结药物的释放效率也有所不同。

Studies on the cubic liquid crystal as a drug delivery system

The cubic phase of lyotropic liquid crystalline systems formed by Monoolein (MO)/ (PEO)_ 99-(PPO)_ 67- (PEO)_ 99 (F127)/H_2O can be dispersed in water, which can be used as a drug delivery system. The atomic force microscopy (AFM) and dynamic laser-light scattering (DLS) methods were used to determine the morphology and size of these cubic liquid crystalline particles, and the ultraviolet-visible adsorption spectrometry and the high performance liquid chromatography (HPLC) were used to characterize the release efficiency of aspirin and caffeine from these particles, respectively. The results show that the amount of MM, MP and F127 have different influences on the drug release efficiency. MP can enhance the release efficiency of aspirin from the cubic liquid crystalline particles, while MM can decrease drug release efficiency. F127 can enhance the drug release efficiency when its amount in the precursor reaches to 20% (w/w). The results also show that the drug release efficiencies are different by using the different solvents to prepare the precursors.