首页 | 本学科首页   官方微博 | 高级检索  
     检索      


BiP (GRP78), an essential hsp70 resident protein in the endoplasmic reticulum
Authors:I G Haas
Institution:1. Institut für Biochemie der Universit?t Heidelberg, Im Neuenheimer Feld 328, D-69120, Heidelberg, (Germany)
Abstract:BiP is a constitutively-expressed resident protein of the endoplasmic, reticulum (ER) of all eucaryotic cells, and belongs to the highly conserved hsp70 protein family. In the ER, BiP is involved in polypeptide translocation, protein folding and presumably protein degradation as well. These functions are essential to cell viability, as has been shown for yeast. In this review, I will summarize the structural features of hsp70 proteins and focus on those experiments which revealed the biological function of BiP.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号