Common variants of FUT2 are associated with plasma vitamin B12 levels |
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| Authors: | Hazra Aditi Kraft Peter Selhub Jacob Giovannucci Edward L Thomas Gilles Hoover Robert N Chanock Stephen J Hunter David J |
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| Institution: | Department of Epidemiology, Harvard School of Public Health, Program in Molecular and Genetic Epidemiology, Boston, Massachusetts 02115, USA. |
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| Abstract: | We identified a strong association (P = 5.36 x 10(-17)) between rs492602 in FUT2 and plasma vitamin B(12) levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602G] allele had higher B(12) levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels. |
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